Xu et al. sought to assess novel pathways by which progestational agents may modify signal transduction pathways that are involved in cervical ripening. For microarray analysis, pregnant CD-1 dams were randomized to subcutaneous injection with either medroxyprogesterone acetate or EtOH (vehicle) at embryonic day 15. Cervical tissues from each treatment group were harvested 48 hours after injection.

Tissue Condition Samples
Test uterine cervix medroxyprogesterone acetate-treated female 6
Control uterine cervix vehicle-treated control 6
Gene Fold Change (log2) Significance Genus Species