Rosenberg et al. conducted a preliminary investigation to determine whether ethanol-induced alterations in placental gene expression may have some utility as a diagnostic indicator of maternal drinking during pregnancy and as a prognostic indicator of risk for adverse neurobehavioral outcomes in affected offspring. Pregnant Long-Evans rats voluntarily consumed either a 0% or 5% ethanol solution 4 hours each day throughout gestation. Placentas were harvested on gestational day 20 for gene expression studies.

Tissue Condition Samples
Test placenta ethanol consumption 4
Control placenta no ethanol consumption 3
Gene Fold Change (log2) Significance Genus Species