Tsai et al. conducted microarray profiling on a large set of human placentas (23 preeclamptic, 37 control) in order to uncover gene expression patterns associated with preeclampsia. Women were diagnosed with preeclampsia if their systolic blood pressure was at least 140 mm Hg, their diastolic blood pressure was at least 90 mm Hg, and they had proteinuria with an estimated 300 mg of protein or greater excreted in 24 hours measured directly or indirectly by protein creatinine ratio. Placental samples approximately 2 cm³ in size were dissected within 5 cm of the umbilical insertion site.

Tissue Condition Samples
Test placenta preeclamptic pregnancy 23
Control placenta normal pregnancy 37
Gene Fold Change (log2) Significance Genus Species