Meng et al. performed a comprehensive analysis of gene expression profiles in placentas from preeclamptic pregnancies versus normal placentas. Placental tissues were obtained immediately after delivery from women with normal pregnancies and patients with preeclampsia. Preeclampsia was diagnosed when both pregnancyinduced hypertension and proteinuria were present. All women were delivered via elective cesarean delivery without labor to eliminate the effect of labor. Tissue blocks (approximately 1 cm³ each) were dissected from the standard locations on the maternal face of the placentas as previously described by Sood et al., 2006. Villous portions were harvested by dissecting free of blood vessels and connective tissue and washing off adherent blood clots.

Tissue Condition Samples
Test chorionic villus preeclamptic pregnancy 6
Control chorionic villus normal pregnancy 6
Gene Fold Change (log2) Significance Genus Species