Pantham et al. investigated the molecular changes that occur in placental explants upon treatment with antiphospholipid antibodies (aPL) in order to begin to understand how these antibodies change trophoblast death. Three first-trimester placentas (8–8.5 weeks) were obtained following elective termination of pregnancies, dissected into explants, and cultured with either 25 μg/ml aPL or untreated media for 16 hours. Microarray analysis was subsequently performed using RNA extracted from the cultured explants.

Tissue Condition Samples
Test placenta antiphospholipid antibody treatment 3
Control placenta untreated control 3
Gene Fold Change (log2) Significance Genus Species