Heng et al. utilized microarray profiling to characterize whole blood gene expression in women with threatened preterm labor (TPTL). Peripheral blood was collected at point of hospital admission from 154 women with threatened preterm labor before any medical treatment. Participants were stratified into two groups: spontaneous preterm birth (sPTB) within 48 hours of hospital admission and no sPTB within 48 hours. Exclusion criteria included excessive antepartum hemorrhage, preterm prelabor rupture of membranes, clinical chorioamnionitis, fetal anomaly, preeclampsia, intrauterine growth restriction, diabetes mellitus, gestational diabetes, or multi-fetal pregnancy.

Tissue Condition Samples
Test blood preterm birth at >7 days and <37 weeks 15
Control blood preterm birth after 48 hours and within 7 days 12
Gene Fold Change (log2) Significance Genus Species