Heng et al. characterized the gene expression profiles of whole blood from women with threatened preterm labor. Peripheral blood was collected at point of hospital admission from 154 women with threatened preterm labor before any medical treatment. Participants were stratified into two groups: spontaneous preterm birth (sPTB) within 48 hours of hospital admission and no sPTB within 48 hours. Exclusion criteria included excessive antepartum hemorrhage, preterm prelabor rupture of membranes, clinical chorioamnionitis, fetal anomaly, preeclampsia, intrauterine growth restriction, diabetes mellitus, gestational diabetes, or multi-fetal pregnancy.

Tissue Condition Samples
Test blood term delivery 79
Control blood preterm birth after 7 days 15
Gene Fold Change (log2) Significance Genus Species