Textoris et al. used microarray profiling to study the transcriptional signature of blood samples associated with preeclampsia. The study included 13 women with severe preeclampsia, 6 women with non-severe preeclampsia, and 19 women with normal pregnancies. The criteria used to define severe preeclampsia included one of the following conditions: blood pressure higher than 160/110 mmHg, proteinuria higher than 1500 mg/24 h, maternal cerebral symptoms (seizures, stroke), intrauterine growth restriction below the 3° percentile, or multisystem disorder. Blood samples were collected from participants at the time of study inclusion.