To investigate fetal gene expression in obese women compared to lean women in the second trimester, Edlow et al. performed global gene expression analysis of amniotic fluid cell-free RNA. Samples were collected from women with a BMI ≥30 (obese) or <25 (lean) undergoing second trimester (14–24 weeks) genetic amniocentesis. Fetuses later found to have an abnormal karyotype were excluded from the study.
|Test||amniotic fluid||obese mother||8|
|Control||amniotic fluid||lean mother||8|
|Gene||Fold Change (log2)||Significance||Genus||Species|