Marcellin et al. explored changes in the choriodecidua of women with endometriosis through genomic and epigenomic microarray analyses in order to gain insight into the intrinsic molecular mechanisms involved in endometriosis. Cases, all affected with painful deep infiltrating endometriosis, were either operated before pregnancy for complete surgical resection of the endometriotic lesions, or had a complete imaging workup before pregnancy that confirmed the diagnosis of endometriosis. Controls samples were collected from women without past history of either endometriosis or chronic pelvic pain. All women were delivered by cesarean section at term before labor for obstetrical indication following an uneventful pregnancy. Collected fetal membranes were separated from the placenta, and choriodecidua was peeled from the amnion and appropriately prepared for RNA and DNA extractions.

Tissue Condition Samples
Test decidua endometriosis-affected pregnancy 3
Control decidua normal pregnancy 3
Gene Fold Change (log2) Significance Genus Species