Winn et al. profiled gene expression at the human maternal-fetal interface during five gestational age intervals: 14-16, 18-19, 21, 23-24, and 37-40 weeks. Basal plate biopsy specimens were obtained from placentas after second-trimester elective terminations of singleton pregnancies or normal nonlabored singleton pregnancies. Pregnancies complicated by fetal anomalies, hypertension, diabetes, or other significant maternal health issues were excluded.

Tissue Condition Samples
Test decidua 37-40 weeks pregnant 9
Control decidua 23-24 weeks pregnant 6
Gene Fold Change (log2) Significance Genus Species