Pappas et al. conducted a retrospective case-control microarray study that characterized the chorioamniotic membranes of preterm neonates with or without neurocognitive impairment at 18–24 months. Chorioamniotic membrane samples were retrieved from the biological sample bank of Wayne State University and the Perinatology Research Branch of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Cases and controls were singleton neonates born between 23–32 weeks of gestation matched for gestational age. Neurocognitive impairment was defined by a cognitive composite score of <80 with or without associated neuromotor impairment at 18–24 months’ corrected age according to the Bayley Scales of Infant Development, 3rd Edition.

Tissue Condition Samples
Test chorion neurocognitive impairment 14
Control chorion no neurocognitive impairment 14
Gene Fold Change (log2) Significance Genus Species