Deletion of the 3 α2-adrenoceptor subtypes in the mouse results in embryonic lethality associated with a severe defect in the development of the extraembryonic vasculature and reduced activity of the ERK1/2 mitogen-activated protein kinases in the placenta and yolk sac at embryonic day 10.5. To search for antiangiogenic or angiogenic genes that might be dysregulated in the placentae of ADRA2B−/− embryos, Muthig et al. performed microarray expression profiling using RNA isolated from total placentae of E10.5 wild-type and mutant embryos with the maternal ADRA2B+/− genotype.

Tissue Condition Samples
Test placenta ADRA2B−/− genotype 3
Control placenta ADRA2B+/+ genotype 3
Gene Fold Change (log2) Significance Genus Species