Deletion of the 3 α2-adrenoceptor subtypes in the mouse results in embryonic lethality associated with a severe defect in the development of the extraembryonic vasculature and reduced activity of the ERK1/2 mitogen-activated protein kinases in the placenta and yolk sac. To search for antiangiogenic or angiogenic genes that might be dysregulated in the placentas of Adra2b−/− embryos, Muthig et al. performed whole genome expression profiling on wild-type and mutant placentas from pregnant Adra2b+/− mice. Placentas were harvested at embryonic day 10.5 for microarray analysis.

Tissue Condition Samples
Test placenta Adra2b−/− placenta 3
Control placenta wild-type control 3
Gene Fold Change (log2) Significance Genus Species