Muehlenbachs et al. performed a genome-wide analysis of the local human response to sequestered malaria parasites in order to identify genes associated with chronic placental malaria (PM). Placental samples from 20 first time mothers were selected based on PM status and RNA quality. A full thickness biopsy was made from the middle third of the placental disc, and placental villi were dissected at <0.5 mm³, excluding large vessels, stem villi, infarcts, fetal membranes, or decidua from placental tissues.

Tissue Condition Samples
Test chorionic villus acute placental malaria (no inflammation) 3
Control chorionic villus uninfected control (no inflammation) 9
Gene Fold Change (log2) Significance Genus Species