Although alive and fertile, protocadherin-12 (Pcdh12)-deficient mice exhibit two major morphological modifications in their placental phenotype: decreased vascular and cell densities in the labyrinth and a missegregation of the labyrinthine and the junctional zone. To understand the molecular events responsible for these alterations observed in Pcdh12−/− placentas, Rampon et al. performed gene expression profiling on embryonic day 12.5 mutant placentas compared with wild-type placentas.

Tissue Condition Samples
Test placenta Pcdh12−/− placenta 5
Control placenta wild-type control 5
Gene Fold Change (log2) Significance Genus Species