To delineate the mechanism of PGF2α-induced luteolysis, Priyanka et al. studied the global changes in gene expression within the corpus luteum following PGF2α treatment of female bonnet monkeys. PGF2α or PBS (vehicle) was administered to female monkeys via three injections on day 10 of the luteal phase. At 24 hours following either PGF2α or PBS administration, corpus luteum samples were collected, immediately cut into 4-5 pieces, and snap frozen in liquid nitrogen.

Tissue Condition Samples
Test corpus luteum PGF2α treatment 3
Control corpus luteum vehicle treatment 3
Gene Fold Change (log2) Significance Genus Species